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Article

Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1.

Biochemical and biophysical research communications - 16 Jun 2000

Chen X Z, Steel A, Hediger M A

Abstract excerpt

Histidyl residues in peptide transporters PepT1 and PepT2 are believed to participate in proton and substrate binding and to be crucial to the transporters' functional activities. In the present study, we performed mutagenesis of rabbit PepT1. We mutated three histidine residues (H57, H111, and H121) predicted to reside in transmembrane segments, as well as tyrosine residues adjacent to H57. Functional analysis...

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Identifiers

PMID: 10860823
DOI: 10.1006/bbrc.2000.2851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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