Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.

Gastroenterology - 1 Jan 2025

Dooley Sarah A, Kolobova Elena, Burman Andreanna, Kaji Izumi, Digrazia Jessica R, Stubler Rachel, Goldstein Anna, Packirisamy Charulekha, Coutts Alexander W, Saqui-Salces Milena, Gao Nan, Engevik Melinda A, Shub Mitchell D, Goldenring James R, Engevik Amy C

Abstract excerpt

BACKGROUND & AIMS: The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of intracellular substrates. P-glycoprotein is altered in disease, but the mechanisms that regulate the levels of P-glycoprotein are still being explored. The molecular motor myosin Vb (Myo5b) traffics diverse cargo to the apical membrane of...

Topics

Join the communities discussing this publication.

ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Enterocytes
Intestinal Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myosin Heavy Chains

rab GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39299401
DOI: 10.1053/j.gastro.2024.09.007
PMCID: PMC11663138

Genes

MYO5B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.PMID 39299401Read ↗

Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.Semantic proximity Read ↗

Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular LevelSemantic proximity Read ↗

Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.Semantic proximity Read ↗

Loss of MYO5B in Mice Recapitulates Microvillus Inclusion Disease and Reveals an Apical Trafficking Pathway Distinct to Neonatal DuodenumSemantic proximity Read ↗

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.Semantic proximity Read ↗

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral traffickingSemantic proximity Read ↗

Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion diseaseSemantic proximity Read ↗

Recent advances in understanding and managing malabsorption: focus on microvillus inclusion diseaseSemantic proximity Read ↗

Identification of intestinal ion transport defects in microvillus inclusion disease.Semantic proximity Read ↗

Therapy Development for Microvillus Inclusion Disease using Patient-derived EnteroidsSemantic proximity Read ↗

Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-Lined Inclusions and Alterations in Sodium Transporters.Semantic proximity Read ↗

Altered cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.