Article
Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states.
The international journal of neuropsychopharmacology - 1 Jun 2013
Karpyak Victor M, Winham Stacey J, Preuss Ulrich W, Zill Peter, Cunningham Julie M, Walker Denise L, Lewis Kriste A, Geske Jennifer R, Colby Colin L, Abulseoud Osama A, Hall-Flavin Daniel K, Loukianova Larissa L, Schneekloth Terry D, Frye Mark A, Bazov Igor, Heit John A, Bakalkin Georgy, Mrazek David A, Biernacka Joanna M
Abstract excerpt
Synthetic κ-opioid receptor (KOR) agonists induce dysphoric and pro-depressive effects and variations in the KOR (OPRK1) and prodynorphin (PDYN) genes have been shown to be associated with alcohol dependence. We genotyped 23 single nucleotide polymorphisms (SNPs) in the PDYN and OPRK1 genes in 816 alcohol-dependent subjects and investigated their association with: (1) negative craving measured by a subscale of...
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