Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent.

doi:10.1038/srep15670

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Article

Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent.

Scientific reports - 27 Oct 2015

Winham Stacey J, Preuss Ulrich W, Geske Jennifer R, Zill Peter, Heit John A, Bakalkin Georgy, Biernacka Joanna M, Karpyak Victor M

Abstract excerpt

We previously demonstrated that prodynorphin (PDYN) haplotypes and single nucleotide polymorphism (SNP) rs2281285 are associated with alcohol dependence and the propensity to drink in negative emotional states, and recent studies suggest that PDYN gene effects on substance dependence risk may be sex-related. We examined sex-dependent associations of PDYN variation with alcohol dependence and related phenotypes,...

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PMID: 26502829
DOI: 10.1038/srep15670
PMCID: PMC4621530

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PDYN

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