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Article

In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases

15 Feb 2017

Abstract excerpt

RNA editing is an essential post-transcriptional process that creates functional mitochondrial mRNAs in Kinetoplastids. Multiprotein editosomes catalyze pre-mRNA cleavage, uridine (U) insertion or deletion, and ligation as specified by guide RNAs. Three functionally and compositionally distinct editosomes differ by the mutually exclusive presence of the KREN1, KREN2 or KREN3 endonuclease and their associated...

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PMID: 28334821
DOI: 10.1093/nar/gkx116

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