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Article

RNA editing catalytic complexes edit multiple mRNA sites non-processively in Trypanosoma brucei

22 Sept 2023

Abstract excerpt

RNA editing generates mature mitochondrial mRNAs in T. brucei by extensive uridine insertion and deletion at numerous editing sites (ESs) as specified by guide RNAs (gRNAs). The editing is performed by three RNA Editing Catalytic Complexes (RECCs) which each have a different endonuclease in addition to 12 proteins in common resulting in RECC1 that is specific for deletion ESs and RECC2 and RECC3 that are specific...

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PMID: 37742784
DOI: 10.1016/j.molbiopara.2023.111596

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