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Article

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.

Human molecular genetics - 15 Apr 2016

Kumar Ashish, Zhang Jennifer, Tallaksen-Greene Sara, Crowley Michael R, Crossman David K, Morton A Jennifer, Van Groen Thomas, Kadish Inga, Albin Roger L, Lesort Mathieu, Detloff Peter J

Abstract excerpt

Identifying molecular drivers of pathology provides potential therapeutic targets. Differentiating between drivers and coincidental molecular alterations presents a major challenge. Variation unrelated to pathology further complicates transcriptomic, proteomic and metabolomic studies which measure large numbers of individual molecules. To overcome these challenges towards the goal of determining drivers of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26908599
DOI: 10.1093/hmg/ddw040
PMCID: PMC4805312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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