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Article

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.

Human molecular genetics - 15 Jun 2006

Lloret Alejandro, Dragileva Ella, Teed Allison, Espinola Janice, Fossale Elisa, Gillis Tammy, Lopez Edith, Myers Richard H, MacDonald Marcy E, Wheeler Vanessa C

Abstract excerpt

Genetically precise models of Huntington's disease (HD), Hdh CAG knock-in mice, are powerful systems in which phenotypes associated with expanded HD CAG repeats are studied. To dissect the genetic pathways that underlie such phenotypes, we have generated Hdh(Q111) knock-in mouse lines that are congenic for C57BL/6, FVB/N and 129Sv inbred genetic backgrounds and investigated four Hdh(Q111) phenotypes in these...

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PMID: 16687439
DOI: 10.1093/hmg/ddl125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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