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Article

Association between genetic polymorphisms and risk of adolescent idiopathic scoliosis in case-control studies: a systematic review.

Journal of medical genetics - 19 Jan 2024

Terhune Elizabeth, Heyn Patricia, Piper Christi, Wethey Cambria, Monley Anna, Cuevas Melissa, Hadley Miller Nancy

Abstract excerpt

BACKGROUND: Adolescent idiopathic scoliosis (AIS) is a structural lateral spinal curvature of ≥10° with rotation. Approximately 2%-3% of children across populations are affected with AIS, and this condition is responsible for ~$3 billion in costs within the USA. Although AIS is believed to have a strong genetic contribution, clinical translation of identified genetic variants has stalled. METHODS: The databases...

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Identifiers

PMID: 37696603
DOI: 10.1136/jmg-2022-108993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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