Non-coding regulatory variants in adolescent idiopathic scoliosis risk and pathogenesis.

Abstract excerpt

Adolescent idiopathic scoliosis is a common pediatric musculoskeletal disease that has significant impacts on childhood quality of life. Recent genome-wide association studies have identified dozens of genetic risk loci and hundreds of risk variants that primarily reside in non-coding regions of the genome. Follow up studies suggest a complex genetic architecture in which several tissues may be affected, however...

Topics

• Humans
• Scoliosis
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Adolescent
• Genetic Variation
• Risk Factors