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Article

BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor.

BMC urology - 21 Mar 2017

Eckel-Passow Jeanette E, Serie Daniel J, Cheville John C, Ho Thai H, Kapur Payal, Brugarolas James, Thompson R Houston, Leibovich Bradley C, Kwon Eugene D, Joseph Richard W, Parker Alexander S

Abstract excerpt

BACKGROUND: BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has been shown to be common in primary ccRCC, little is known regarding heterogeneity in metastatic ccRCC tumors. MATERIALS AND METHODS: We analyzed BAP1 and...

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Identifiers

PMID: 28327121
DOI: 10.1186/s12894-017-0209-3
PMCID: PMC5361787

Genes

BAP1
PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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