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Article

Somatic mutations as preoperative predictors of metastases in patients with localized clear cell renal cell carcinoma - An exploratory analysis.

Urologic oncology - 1 Nov 2021

Mano Roy, Duzgol Cihan, Ganat Maz, Goldman Debra A, Blum Kyle A, Silagy Andrew W, Walasek Aleksandra, Sanchez Alejandro, DiNatale Renzo G, Marcon Julian, Kashan Mahyar, Becerra Maria F, Benfante Nicole E, Coleman Jonathan A, Kattan Michael W, Russo Paul, Akin Oguz, Ostrovnaya Irina, Hakimi A Ari

Abstract excerpt

OBJECTIVE: Recurrent genomic alterations in clear cell renal cell carcinoma (ccRCC) have been associated with treatment outcomes; however, current preoperative predictive models do not include known genetic predictors. We aimed to explore the value of common somatic mutations in the preoperative prediction of metastatic disease among patients treated for localized ccRCC. MATERIALS AND METHODS: After obtaining...

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Identifiers

PMID: 34580025
DOI: 10.1016/j.urolonc.2021.08.018
PMCID: PMC8601021

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