Article
Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017
Cao Chan, Wang Shuqing, Cui Tanxing, Su Xun-Cheng, Chou James J
Abstract excerpt
The calcium (Ca2+) uniporter of mitochondria is a holocomplex consisting of the Ca2+-conducting channel, known as mitochondrial calcium uniporter (MCU), and several accessory and regulatory components. A previous electrophysiology study found that the uniporter has high Ca2+ selectivity and conductance and this depends critically on the conserved amino acid sequence motif, DXXE (Asp-X-X-Glu) of MCU. A recent NMR...
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