Article
Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter.
EMBO reports - 1 Oct 2015
Lee Youngjin, Min Choon Kee, Kim Tae Gyun, Song Hong Ki, Lim Yunki, Kim Dongwook, Shin Kahee, Kang Moonkyung, Kang Jung Youn, Youn Hyung-Seop, Lee Jung-Gyu, An Jun Yop, Park Kyoung Ryoung, Lim Jia Jia, Kim Ji Hun, Kim Ji Hye, Park Zee Yong, Kim Yeon-Soo, Wang Jimin, Kim Do Han, Eom Soo Hyun
Abstract excerpt
The mitochondrial calcium uniporter (MCU) is responsible for mitochondrial calcium uptake and homeostasis. It is also a target for the regulation of cellular anti-/pro-apoptosis and necrosis by several oncogenes and tumour suppressors. Herein, we report the crystal structure of the MCU N-terminal domain (NTD) at a resolution of 1.50 Å in a novel fold and the S92A MCU mutant at 2.75 Å resolution; the residue S92...
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