Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake.

Journal of cellular physiology - 1 Apr 2025

Rai Neeraj K, Eberhardt David R, Balynas Anthony M, MacEwen Melissa J S, Bratt Ashley R, Sancak Yasemin, Chaudhuri Dipayan

Abstract excerpt

Mitochondrial Ca2+ levels are regulated to balance stimulating respiration against the harm of Ca2+ overload. Contributing to this balance, the main channel transporting Ca2+ into the matrix, the mitochondrial Ca2+ uniporter, can incorporate a dominant-negative subunit (MCUB). MCUB is homologous to the pore-forming subunit MCU, but when present in the pore-lining tetramer, inhibits Ca2+ transport. Here, using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Mitochondria

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40227803
DOI: 10.1002/jcp.70033
PMCID: PMC11996009

Genes

MCUB
MCU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake.PMID 40227803Read ↗

Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.Semantic proximity Read ↗

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.Semantic proximity Read ↗

MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophySemantic proximity Read ↗

Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1Semantic proximity Read ↗

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.Semantic proximity Read ↗

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.Semantic proximity Read ↗

The In Vivo Biology of the Mitochondrial Calcium Uniporter.Semantic proximity Read ↗

Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease modelsSemantic proximity Read ↗

Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death.Semantic proximity Read ↗

MICU1 modulates MCU ion selectivity and tolerance to manganese stressSemantic proximity Read ↗

TMEM65-dependent Ca <sup>2+</sup> extrusion safeguards mitochondrial homeostasisSemantic proximity Read ↗

PHB2 forms a mitochondrial calcium channel that drives Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.