Article

MICU1 modulates MCU ion selectivity and tolerance to manganese stress

2018-07-17

Abstract excerpt

<h4>SUMMARY</h4> The mitochondrial calcium uniporter is a highly selective ion channel composed of species-and tissue-specific structural and regulatory subunits. However, the contribution of each component to uniporter-mediated activity still remains unclear. Here, we employ an evolutionary and synthetic biology approach to investigate the functional inter-dependence between the pore-forming subunit MCU and the...

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Literature Corpus work: c1c4ef53-d715-57c5-ba2f-f9e01614f23a
DOI: 10.1101/371419

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