Article
Association between variants in genes involved in the immune response and prostate cancer risk in men randomized to the finasteride arm in the Prostate Cancer Prevention Trial.
The Prostate - 1 Jun 2017
Winchester Danyelle A, Till Cathee, Goodman Phyllis J, Tangen Catherine M, Santella Regina M, Johnson-Pais Teresa L, Leach Robin J, Xu Jianfeng, Zheng S Lilly, Thompson Ian M, Lucia M Scott, Lippman Scott M, Parnes Howard L, Isaacs William B, De Marzo Angelo M, Drake Charles G, Platz Elizabeth A
Abstract excerpt
BACKGROUND: We reported that some, but not all single nucleotide polymorphisms (SNPs) in select immune response genes are associated with prostate cancer, but not individually with the prevalence of intraprostatic inflammation in the Prostate Cancer Prevention Trial (PCPT) placebo arm. Here, we investigated whether these same SNPs are associated with risk of lower- and higher-grade prostate cancer in men...
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