Article
Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial.
The Prostate - 1 Sept 2015
Winchester Danyelle A, Till Cathee, Goodman Phyllis J, Tangen Catherine M, Santella Regina M, Johnson-Pais Teresa L, Leach Robin J, Xu Jianfeng, Zheng S Lilly, Thompson Ian M, Lucia M Scott, Lippmann Scott M, Parnes Howard L, Dluzniewski Paul J, Isaacs William B, De Marzo Angelo M, Drake Charles G, Platz Elizabeth A
Abstract excerpt
BACKGROUND: We previously found that inflammation in benign prostate tissue is associated with an increased odds of prostate cancer, especially higher-grade disease. Since part of this link may be due to genetics, we evaluated the association between single nucleotide polymorphisms (SNPs) in immune response genes and prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial. METHODS: We genotyped...
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