Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk.

doi:10.1093/carcin/bgq081

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Article

Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk.

Carcinogenesis - 1 Oct 2010

Tindall E A, Severi G, Hoang H N, Ma C S, Fernandez P, Southey M C, English D R, Hopper J L, Heyns C F, Tangye S G, Giles G G, Hayes V M

Abstract excerpt

Although inflammation is emerging as a candidate prostate cancer risk factor, the T-helper cytokine-rich [interleukins (IL)-5, 13 and 4] chromosomal region at 5q31.1 has been implicated in prostate cancer pathogenesis. In particular, IL-4 has been associated with prostate cancer progression, whereas the IL-4 -589C>T (rs2243250) promoter variant has been associated with differential gene expression. We genotyped...

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PMID: 20403914
DOI: 10.1093/carcin/bgq081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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