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Article

An Analytic Solution to the Computation of Power and Sample Size for Genetic Association Studies under a Pleiotropic Mode of Inheritance.

Human heredity - 1 Jan 2016

Gordon Derek, Londono Douglas, Patel Payal, Kim Wonkuk, Finch Stephen J, Heiman Gary A

Abstract excerpt

Our motivation here is to calculate the power of 3 statistical tests used when there are genetic traits that operate under a pleiotropic mode of inheritance and when qualitative phenotypes are defined by use of thresholds for the multiple quantitative phenotypes. Specifically, we formulate a multivariate function that provides the probability that an individual has a vector of specific quantitative trait values...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28315880
DOI: 10.1159/000457135
PMCID: PMC5577944

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