Article
Genome-Wide Splicing Quantitative Expression Locus Analysis Identifies Causal Risk Variants for Non-Small Cell Lung Cancer.
Cancer research - 15 May 2023
Jin Meng, Liu Bo, Chen Can, Huang Yongbiao, Zhang Huixian, Chen Bingliang, Song Guoda, Zhao Dong, Duan Limin, Liu Wei, Yang Haizhen, Yue Fang, Liu Peijun, Yuan Xianglin, Chu Qian, Tian Jianbo, Hu Ke
Abstract excerpt
Alternative RNA splicing is an essential mechanism linking genetic variation to human diseases. While the signals from genome-wide association studies (GWAS) have been linked to expression quantitative trait loci (eQTL) in previous studies, further work is needed to better elucidate the relationship to other genetic regulatory mechanisms, such as splicing QTLs (sQTL). Here, we performed a genome-wide sQTL...
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