Article

Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression

2026-03-30

Abstract excerpt

Genetic regulation of splicing uniquely contributes to trait-associated genome-wide association studies (GWAS) signals. However, quantitative trait loci (QTL) analysis using short-read sequencing of bulk tissues fails to capture full-length and cell-type-specific isoforms. Here, we present an isoform-level lung cell atlas from 129 never-smoking Korean women using single-cell long-read RNA-sequencing, identifying a...

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Literature Corpus work: 5a0037c5-80e2-535c-a552-21eb709d308a
DOI: 10.64898/2026.03.27.714873

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