Article
Adenylyl cyclase localization regulates streaming during chemotaxis.
Cell - 21 Feb 2003
Kriebel Paul W, Barr Valarie A, Parent Carole A
Abstract excerpt
We studied the role of the adenylyl cyclase ACA in Dictyostelium discoideum chemotaxis and streaming. In this process, cells orient themselves in a head to tail fashion as they are migrating to form aggregates. We show that cells lacking ACA are capable of moving up a chemoattractant gradient, but are unable to stream. Imaging of ACA-YFP reveals plasma membrane labeling highly enriched at the uropod of polarized...
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