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Article

Age-dependent loss of cohesion protection in human oocytes

21 Dec 2023

Abstract excerpt

Aneuploid human eggs (oocytes) are a major cause of infertility, miscarriage, and chromosomal disorders. Such aneuploidies increase greatly as women age, with defective linkages between sister chromatids (cohesion) in meiosis as a common cause. We found that loss of a specific pool of the cohesin protector protein, shugoshin 2 (SGO2), may contribute to this phenomenon. Our data indicate that SGO2 preserves sister...

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PMID: 38134935
DOI: 10.1016/j.cub.2023.11.061

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