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Article

Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.

Cardiovascular research - 1 May 2010

Furgeson Seth B, Simpson Peter A, Park Insun, Vanputten Vicki, Horita Henrick, Kontos Christopher D, Nemenoff Raphael A, Weiser-Evans Mary C M

Abstract excerpt

AIMS: Phosphatase and tensin homolog (PTEN) is implicated as a negative regulator of vascular smooth muscle cell (SMC) proliferation and injury-induced vascular remodelling. We tested if selective depletion of PTEN only in SMC is sufficient to promote SMC phenotypic modulation, cytokine production, and enhanced neointima formation. METHODS AND RESULTS: Smooth muscle marker expression and induction of...

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Source

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Identifiers

PMID: 20051384
DOI: 10.1093/cvr/cvp425
PMCID: PMC2856191

Genes

PTEN
CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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