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Article

Smooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries.

Physiological reports - 1 Dec 2016

Liao Mingmei, Yang Pu, Wang Fen, Berceli Scott A, Ali Yasmin H, Chan Kelvin L, Jiang Zhihua

Abstract excerpt

Neointimal hyperplasia (NIH) and inward wall remodeling cause arterial restenosis and failure of bypass vein grafts. Previous studies from our group suggest that transforming growth factor (TGF) β promotes these pathologies via regulating cell kinetics at the early stage and matrix metabolism at the late stage. Although these temporal TGFβ effects may result from its signaling in different cell groups, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Transforming Growth Factor-beta Type I

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Source

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Identifiers

PMID: 27923978
DOI: 10.14814/phy2.13056
PMCID: PMC5357823

Genes

MMP9
TGFBR1

Provenance

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