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Genetically predicted serum uric acid levels and the risk of coronary artery disease in patients with diabetes: A Mendelian randomization study.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 7 Jun 2021

Chen Songzan, Yang Fangkun, Xu Tian, Wang Yao, Zhang Kaijie, Fu Guosheng, Zhang Wenbin

Abstract excerpt

BACKGROUND AND AIMS: Serum uric acid (SUA) levels have been reported to be associated with an increased risk of coronary artery disease (CAD) among patients with diabetes in observational study. Whether this relationship is causal remains unclear. The current study aimed to explore the causal association between SUA and the risk of CAD in patients with diabetes. METHODS AND RESULTS: A two-sample Mendelian...

Topics

Biomarkers
Case-Control Studies
Coronary Artery Disease
Diabetes Mellitus
Genome-Wide Association Study
Humans
Hyperuricemia
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Risk Assessment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Up-Regulation

Uric Acid

Source

Identifiers

PMID: 33975736
DOI: 10.1016/j.numecd.2021.03.007

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