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Contributions of elevated CRP, hyperglycaemia, and type 2 diabetes to cardiovascular risk in the general population: observational and Mendelian randomization studies.

Cardiovascular diabetology - 10 May 2024

Rolver Monica G, Emanuelsson Frida, Nordestgaard Børge G, Benn Marianne

Abstract excerpt

OBJECTIVE: To investigate the contributions of low-grade inflammation measured by C-reactive protein (CRP), hyperglycaemia, and type 2 diabetes to risk of ischemic heart disease (IHD) and cardiovascular disease (CVD) death in the general population, and whether hyperglycaemia and high CRP are causally related. RESEARCH DESIGN AND METHODS: Observational and bidirectional, one-sample Mendelian randomization (MR)...

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Identifiers

PMID: 38730445
DOI: 10.1186/s12933-024-02207-0
PMCID: PMC11088022

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