Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.

doi:10.1016/j.atherosclerosis.2015.05.033

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Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.

Atherosclerosis - 1 Aug 2015

Jansen Henning, Loley Christina, Lieb Wolfgang, Pencina Michael J, Nelson Christopher P, Kathiresan Sekar, Peloso Gina M, Voight Benjamin F, Reilly Muredach P, Assimes Themistocles L, Boerwinkle Eric, Hengstenberg Christian, Laaksonen Reijo, McPherson Ruth, Roberts Robert, Thorsteinsdottir Unnur, Peters Annette, Gieger Christian, Rawal Rajesh, Thompson John R, König Inke R, Vasan Ramachandran S, Erdmann Jeanette, Samani Nilesh J, Schunkert Heribert

Abstract excerpt

BACKGROUND: The mechanisms underlying the association between diabetes and coronary artery disease (CAD) risk are unclear. We aimed to assess this association by studying genetic variants that have been shown to associate with type 2 diabetes (T2DM). If the association between diabetes and CAD is causal, we expected to observe an association of these variants with CAD as well. METHODS AND RESULTS: We studied all...

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PMID: 26074316
DOI: 10.1016/j.atherosclerosis.2015.05.033
PMCID: PMC4536952

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