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Article

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure.

The Journal of biological chemistry - 28 Apr 2017

Lee Hakjoo, Smith Sylvia B, Yoon Yisang

Abstract excerpt

The protein optic atrophy 1 (OPA1) is a dynamin-related protein associated with the inner mitochondrial membrane and functions in mitochondrial inner membrane fusion and cristae maintenance. Inner membrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1). It is often thought that S-OPA1 is a functionally insignificant proteolytic product of L-OPA1 because the...

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Source

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Identifiers

PMID: 28298442
DOI: 10.1074/jbc.M116.762567
PMCID: PMC5409478

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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