Article
Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.
Protein science : a publication of the Protein Society - 1 Aug 2017
Shields Kaitlyn M, Tooley John G, Petkowski Janusz J, Wilkey Daniel W, Garbett Nichola C, Merchant Michael L, Cheng Alan, Schaner Tooley Christine E
Abstract excerpt
A subset of B-cell lymphoma patients have dominant mutations in the histone H3 lysine 27 (H3K27) methyltransferase EZH2, which change it from a monomethylase to a trimethylase. These mutations occur in aromatic resides surrounding the active site and increase growth and alter transcription. We study the N-terminal trimethylase NRMT1 and the N-terminal monomethylase NRMT2. They are 50% identical, but differ in key...
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