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Article

Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity.

Biochemistry - 13 Nov 2007

Chou Tsui-Fen, Sham Yuk Y, Wagner Carston R

Abstract excerpt

Although highly sequence similar, human histidine triad nucleotide binding protein (hHint1) and E. coli hinT (echinT) exhibit significant differences in their phosphoramidase substrate specificity and lysyl-adenylate hydrolytic activity. Observing that the C termini of each enzyme are highly dissimilar, we created two chimeric Hint's: one in which the C terminus of hHint1 was replaced with the C terminus of...

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PMID: 17939685
DOI: 10.1021/bi701244h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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