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Article

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Mar 2015

Green Michael R, Kihira Shingo, Liu Chih Long, Nair Ramesh V, Salari Raheleh, Gentles Andrew J, Irish Jonathan, Stehr Henning, Vicente-Dueñas Carolina, Romero-Camarero Isabel, Sanchez-Garcia Isidro, Plevritis Sylvia K, Arber Daniel A, Batzoglou Serafim, Levy Ronald, Alizadeh Ash A

Abstract excerpt

Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course typified by multiple relapses after therapy. These tumors are genetically characterized by B-cell leukemia/lymphoma 2 (BCL2) translocation and mutation of genes involved in chromatin modification. By analyzing purified tumor cells, we identified additional novel recurrently mutated genes and confirmed mutations of one or...

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Share to Antigen-Presenting Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

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Source

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Identifiers

PMID: 25713363
DOI: 10.1073/pnas.1501199112
PMCID: PMC4364211

Genes

CREBBP
BCL2
CIITA

Provenance

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