Exhaustion-associated regulatory regions in CD8 + tumor-infiltrating T cells

Abstract excerpt

Significance Cancer cells can be recognized and attacked by CD8 + cytolytic T cells, but tumor-infiltrating T cells often become functionally incompetent (“exhausted”) and fail to destroy tumor cells. We show that T-cell exhaustion requires antigen recognition by tumor-infiltrating T cells. By examining the transcriptional and chromatin accessibility profiles of antigen-reactive and -unreactive tumor-infiltrating...

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