Article

Degradation of IKAROS prevents epigenetic progression of T cell exhaustion in a novel antigen-specific assay

2024-02-24

Abstract excerpt

In cancer, chronic antigen stimulation drives effector T cells to exhaustion, limiting the efficacy of T cell therapies. Recent studies have demonstrated that epigenetic rewiring governs the transition of T cells from effector to exhausted states and makes a subset of exhausted T cells non-responsive to PD1 checkpoint blockade. Here, we describe an antigen-specific assay for T cell exhaustion that generates T cell...

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Literature Corpus work: 33721699-8ee3-57bd-b2b0-9a1536e5dbe9
DOI: 10.1101/2024.02.22.581548

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