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Article

Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14.

Cancer research - 15 May 2017

Du Yongxing, Liu Ziwen, You Lei, Hou Pengjiao, Ren Xiaoxia, Jiao Tao, Zhao Wenjing, Li Zongze, Shu Hong, Liu Changzheng, Zhao Yupei

Abstract excerpt

Mutant p53 (mutp53) proteins promote tumor invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC). However, the mechanism underlying sustained activation of mutp53 oncogenic signaling is currently unclear. In this study, we report that NOP14 nucleolar protein (NOP14) expression is upregulated in PDAC tumors and metastatic tissue specimens. NOP14 overexpression promoted cell motility, whereas NOP14...

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Source

Identifiers

PMID: 28280038
DOI: 10.1158/0008-5472.CAN-16-2339

Genes

NOP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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