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NudCL2 suppresses pancreatic cancer progression by inhibiting SLC7A11-mediated EMT and metastasis

1 Sept 2025

Abstract excerpt

Pancreatic cancer (PC) is a highly aggressive malignancy with limited therapeutic options and poor prognosis. NudC-like protein 2 (NudCL2), a molecular cochaperone of HSP90, has been implicated in various cellular processes; however, its role in pancreatic cancer remains poorly understood. In this study, we report that NudCL2 expression is significantly downregulated in PC tissues and is correlated with poor...

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PMID: 40907782
DOI: 10.1016/j.yexcr.2025.114730

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