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Article

STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer

21 Aug 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) poses a serious clinical challenge, demanding further exploration of its pathogenesis and therapeutic targets for metastasis, the main cause of mortality. Here, we identify STN1, a CST complex member crucial for maintaining telomere lengths and genome stability, as a key factor in promoting PDAC metastasis. Elevated STN1 levels correlate with poor patient survival, with...

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PMID: 40841373
DOI: 10.1038/s41467-025-63083-0

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