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Article

Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway.

Oncotarget - 30 Jan 2015

Duan Wanxing, Li Rong, Ma Jiguang, Lei Jianjun, Xu Qinhong, Jiang Zhengdong, Nan Ligang, Li Xuqi, Wang Zheng, Huo Xiongwei, Han Liang, Wu Zheng, Wu Erxi, Ma Qingyong

Abstract excerpt

Metastasis is the major cause for the high mortality rate of pancreatic cancer. Human embryonic stem cell (hESC) associated genes frequently correlate with malignant disease progression. Recent studies have demonstrated that the embryonic protein Nodal, which plays a critical role during embryonic development, is re-expressed in several types of tumors and promotes cancers progression. However, little is known...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25557170
DOI: 10.18632/oncotarget.2686
PMCID: PMC4359309

Genes

CXCR4
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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