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Article

LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment

30 Mar 2018

Abstract excerpt

Metastasis to distant organs is a particularly ominous feature of malignant cancer. LKB1 (also known as STK11) has been identified as a tumor suppressor in several types of cancers. Here, we show that LKB1 is at low levels and is negatively associated with poor clinical outcomes in pancreatic cancer (PC). LKB1 is inversely correlated with Snail protein in PC, in which the loss of LKB1 facilitates metastasis...

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PMID: 29601127
DOI: 10.1111/cas.13591

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