Article

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse models

2023-10-29

Abstract excerpt

<title>Abstract</title> <p>CIC-DUX4 sarcoma (CDS) is a rare but highly aggressive undifferentiated small round cell sarcoma driven by a fusion between the tumor suppressor Capicua (CIC) and DUX4. Currently, there are no effective treatments and efforts to identify and translate better therapies are limited by the scarcity of patient tumor samples and cell lines. To address this limitation, we generated three gene...

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Literature Corpus work: fd952caf-107b-5bcf-9546-6c5a889b5793
DOI: 10.21203/rs.3.rs-3487637/v1

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