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Article

Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development

20 Dec 2016

Abstract excerpt

Kidney formation involves patterning events that induce renal progenitors to form nephrons with an intricate composition of multiple segments. Here, we performed a chemical genetic screen using zebrafish and discovered that prostaglandins, lipid mediators involved in many physiological functions, influenced pronephros segmentation. Modulating levels of prostaglandin E2 (PGE2) or PGB2 restricted distal segment...

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PMID: 27996936
DOI: 10.7554/elife.17551

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