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Article

Neonatal RAS inhibition changes the phenotype of the developing thick ascending limb of Henle.

American journal of physiology. Renal physiology - 1 Jun 2004

Lasaitiene Daina, Friberg Peter, Sundelin Birgitta, Chen Yun

Abstract excerpt

Pharmacological interruption of angiotensin II type 1 (AT(1)) receptor signaling during nephrogenesis in rats perturbs renal tubular development. Perturbed tubulogenesis may contribute to long-term impairment of urinary concentrating ability, which is the main functional irreversible defect. The aim of this study was to further characterize tubular developmental deficits in neonatal rats, focusing on the thick...

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Identifiers

PMID: 14871879
DOI: 10.1152/ajprenal.00236.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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