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Article

Critical APJ receptor residues in extracellular domains that influence effector selectivity.

The FEBS journal - 1 Nov 2021

Ashokan Anisha, Harisankar Harikumar Sheela, Kameswaran Mythili, Aradhyam Gopala Krishna

Abstract excerpt

Human APJ receptor/apelin receptor (APJR), activated by apelin peptide isoforms, regulates a wide range of physiological processes. The role of extracellular loop (ECL) domain residues of APJR in ligand binding and receptor activation has not been established yet. Based on multiple sequence alignment of APJ receptor from various organisms, we identified conserved residues in the extracellular domains. Alanine...

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PMID: 34076959
DOI: 10.1111/febs.16048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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