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Article

Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene.

Scientific reports - 8 Mar 2017

Tremblay Johanne, Wang Yujia, Raelson John, Marois-Blanchet Francois-Christophe, Wu Zenghui, Luo Hongyu, Bradley Edward, Chalmers John, Woodward Mark, Harrap Stephen, Hamet Pavel, Wu Jiangping

Abstract excerpt

EPH kinases and their ligands, ephrins (EFNs), have vital and diverse biological functions. We recently reported that Efnb3 gene deletion results in hypertension in female but not male mice. These data suggest that EFNB3 regulates blood pressure in a sex- and sex hormone-dependent way. In the present study, we conducted a human genetic study to assess the association of EFNB3 single nucleotide polymorphisms with...

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Source

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Identifiers

PMID: 28272517
DOI: 10.1038/srep44114
PMCID: PMC5341021

Genes

EFNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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