Article
Reduced blood pressure after smooth muscle EFNB2 deletion and the potential association of EFNB2 mutation with human hypertension risk.
European journal of human genetics : EJHG - 1 Dec 2016
Wang Yujia, Hamet Pavel, Thorin Eric, Tremblay Johanne, Raelson John, Wu Zenghui, Luo Hongyu, Jin Wei, Lavoie Julie L, Peng Junzheng, Marois-Blanchet Francois-Christophe, Tahir Muhammad Ramzan, Chalmers John, Woodward Mark, Harrap Stephen, Qi Shijie, Li Charles Yibin, Wu Jiangping
Abstract excerpt
Ephrin B2 (EFNB2) is a ligand for erythropoietin-producing hepatocellular kinases (EPH), the largest family of receptor tyrosine kinases. It has critical functions in many biological systems, but is not known to regulate blood pressure. We generated mice with a smooth muscle cell (SMC)-specific deletion of EFNB2 and investigated its roles in blood pressure regulation and vascular SMC (VSMC) contractility. Male...
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