Article
Novel genetic variation in exon 28 of FBN1 gene is associated with essential hypertension.
American journal of hypertension - 1 Jun 2011
Shen Chong, Lu Xiangfeng, Wang Laiyuan, Chen Shufeng, Li Yun, Liu Xiaoli, Li Jianxin, Huang Jianfeng, Gu Dongfeng
Abstract excerpt
BACKGROUND: Recently, fibrillin-1 (FBN1) was reported to play an important role in maintaining the physiological arterial stiffness of essential hypertension (EH). Here, we designed a two-stage case-control study to investigate whether the FBN1 gene harbored any genetic variations associated with EH. METHODS: In stage 1, six candidate single-nucleotide polymorphisms (SNPs) of the FBN1 gene were genotyped and...
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