Article
The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.
The pharmacogenomics journal - 1 Aug 2021
Liu Chunlan, Tang Wuzhuang, Zhao Hailong, Yang Song, Ren Zhanyun, Li Jie, Chen Yanchun, Zhao Xianghai, Xu Donghua, Zhao Yanping, Shen Chong
Abstract excerpt
BACKGROUND: Filamin A and filamin B were involved in vascular development and remodeling. Herein, it is important to explore the associations of FLNA and FLNB variants with hypertension and stroke. METHODS: The associations of two single-nucleotide polymorphisms (SNPs) at FLNA and five SNPs at FLNB with hypertension and stroke were examined in two case-control studies and a cohort study in Chinese Han population....
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