Article
Effect-specific analysis of pathogenic SNVs in human interactome: Leveraging edge-based network robustness.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Aug 2016
Hongzhu Cui, Korkin Dmitry
Abstract excerpt
Study of genetic variants in the context of molecular networks has recently gained much attention. However, many of these studies suffer from the lack of functional information about the network rewiring effect of genetic variants. After large-scale homology modeling, plus extracting native structure from PDB database, we performed structure-based prediction about the rewiring effect using our SNP-IN tool, and it...
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