Article
Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis.
BMC nephrology - 13 May 2015
Brunskill Eric W, Potter S Steven
Abstract excerpt
BACKGROUND: Mutations in several genes expressed in podocytes, including Cd2ap, have been associated with focal segmental glomerulosclerosis in humans. Mutant mouse models provide an opportunity to better understand the molecular pathology that drives these diseases. METHODS: In this report we use a battery of transgenic-GFP mice to facilitate the purification of all three major cell types of the glomerulus from...
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